Angiotensinogen: in-silico insight to mutations, protein-protein interactions and evolution

Autori

  • Misbah Hussain Department of Biotechnology, University of Sargodha, Pakistan Autor
  • Sumaira Nishat Department of Computer Sciences, University of Agriculture, Faisalabad, Pakistan Autor

DOI:

https://doi.org/10.25083/rbl/28.3/3990.3997

Cuvinte cheie:

angiotensinogen, cardiovascular disease, protein-protein interaction, phylogenetic analysis

Rezumat

In this era of rapidly evolving genetic and non-genetic diseases, in-silico analysis of disease related proteins has proven beneficial in identification and characterization of potential therapeutic targets. In present study, angiotensinogen (AGT) was studied for its sequence based ortholog and paralogs, structural characterization, mutational analysis, protein interactions and evolutionary changes. Sequence studies identified 194 orthologs and 36 paralogs of AGT. Functional analysis AGT polymorphisms revealed the association of M235T with increased AGT stability. Protein-protein interaction analysis exposed the involvement of AGT in metabolic diseases. So, this study provided base for the experimentally proven association of M235T polymorphism with metabolic diseases. Moreover, it presents AGT as strong therapeutic target for the control of these diseases.

283-4

Descărcări

Publicat

2024-07-02