Antitumor antibiotics: representatives, mechanisms of action and side effects

Authors

  • GRIGORE MIHAESCU Faculty of Biology, University of Bucharest, 030018 Bucharest, Romania Author
  • MARIAN CONSTANTIN Institute of Biology Bucharest of Romanian Academy, 296 Splaiul Independentei, 060031 Bucharest, Romania Author
  • OCTAVIAN ANDRONIC General Surgery, University of Medicine and Pharmacy “Carol Davila”, 020021 Bucharest, Romania Author
  • ALEXANDRA BOLOCAN General Surgery, University of Medicine and Pharmacy “Carol Davila”, 020021 Bucharest, Romania Author
  • ILINCA VLAD Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia, 020956 Bucharest, Romania Author
  • ROXANA FILIP Faculty of Medicine and Biological Sciences, Stefan cel Mare University of Suceava, 720229 Suceava, Romania Author

DOI:

https://doi.org/10.25083/rbl/27.2/3422.3428

Keywords:

antitumor agents, anthracyclines, peptide antibiotics, quinolones

Abstract

Bacteria and fungi synthesize various compounds necessary for their own metabolism, as well as compounds that kill other microbial strains and species from the environment in which they grow, to ensure their access to sufficient supplies. Since the discovery of their antitumor effect, three main classes of antibiotics are used in cancer therapy: anthracyclines (secondary metabolites, mainly produced by members of Streptomyces group, or semisynthetic derivatives containing the 7,8,9,10-tetrahidrotetracen-5.12 quinone structure), peptide antibiotics and quinolones. In this minireview, we will present the mechanisms of action, main  representatives and side effects of these anti-cancer agents.

Author Biographies

  • MARIAN CONSTANTIN, Institute of Biology Bucharest of Romanian Academy, 296 Splaiul Independentei, 060031 Bucharest, Romania

    Fellow of the Research Institute of the University of Bucharest, ICUB, Bucharest, Romania

  • ROXANA FILIP, Faculty of Medicine and Biological Sciences, Stefan cel Mare University of Suceava, 720229 Suceava, Romania

    Regional County Emergency Hospital, 720284 Suceava, Romania

RBL272-14

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Published

2024-05-23