In vitro Angiotensin Converting Enzyme Inhibitory and Antioxidant Activities of Some Sulfur Compounds

Autori

  • SEBAHAT YILMAZ Istanbul University-Cerrahpasa, Faculty of Engineering Block A, Department of Chemistry, Division of Biochemistry, 34320-Avcilar/Istanbul/TURKEY Autor
  • BERTAN BORAN BAYRAK Istanbul University-Cerrahpasa, Faculty of Engineering Block A, Department of Chemistry, Division of Biochemistry, 34320-Avcilar/Istanbul/TURKEY Autor
  • REFIYE YANARDAG Istanbul University-Cerrahpasa, Faculty of Engineering Block A, Department of Chemistry, Division of Biochemistry, 34320-Avcilar/Istanbul/TURKEY Autor

DOI:

https://doi.org/10.25083/rbl/27.1/3252-3263

Cuvinte cheie:

Free radicals, angiotensin converting enzyme, inhibitors, antioxidant activity, sulfur compounds

Rezumat

The angiotensin converting enzyme (ACE) catalyzes the conversion of angiotensin I to a key vasoconstrictor angiotensin II in renin-angiotensin system (RAS), thus  playing an important role in both regulating blood pressure and maintaining fluid  balance through RAS. Free radicals are continuously produced in the biological  system. Therefore, organisms need both exogenous and endogenous antioxidants  to guard against the damage caused by these free radicals. In this  way, they prevent the occurrence of numerous diseases via protecting cellular components and biomolecules. The aim of the current study was to investigate the  ACE inhibitory and antioxidant activities of sulfur compounds. The ACE  inhibitory and antioxidant activities of all sulfur compounds increased in a  concentration-dependent manner. Among these compounds, methionine had the  highest ACE inhibitory and antioxidant activityes based on reducing power, DPPH  radical scavenging and ORAC methods. Cystine had the highest ABTS radical  scavenging, FRAP and nitrite scavenging activities. However, S-benzyl cysteine and  S-phenyl cysteine exhibited the lowest ACE inhibitory and antioxidant activities,  respectively. These outcomes indicate that sulfur compounds have both ACE  inhibitory and antioxidant activities and may serve as gateways for research  toward understanding the beneficial pharmacological effects of sulfur compounds  against cell damage caused by oxidative stress. 

RBL271-10

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Publicat

2024-05-23